Du Søgte efter: ENZO LIFE SCIENCES

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Beskrivelse: Anti-KDEL Mouse Monoclonal Antibody [clone: 10C3]

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Leverandør: ENZO LIFE SCIENCES

Beskrivelse: The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

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Varenummer: (ENZOALX804167C100)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: Host: Mouse, Isotype: IgM

UOM: 1 * 1 Each

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Varenummer: (ENZOALX804157BC100)

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Beskrivelse: Host: Rat, Isotype: IgG1

UOM: 1 * 1 Each

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Varenummer: (ENZOALX804243C100)

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Beskrivelse: Host: Mouse, Isotype: IgG1 kappa

UOM: 1 * 1 Each

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Beskrivelse: Acetyl-CoA inhibitor

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Varenummer: (ENZOBMLEI2940001)

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Beskrivelse: Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.

UOM: 1 * 1 mg

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Beskrivelse: Src kinase inhibitor

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Beskrivelse: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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Varenummer: (ENZOBMLEI3080001)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: HSP90 inhibitor

UOM: 1 * 1 mg

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Varenummer: (ENZOBMLEI3100005)

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Beskrivelse: Inhibitor of CDK and GSK

UOM: 1 * 5 mg

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Varenummer: (ENZOALX804220R100)

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Beskrivelse: Host: Mouse, Isotype: IgG3

UOM: 1 * 100 µl

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Varenummer: (ENZOALX804148C100)

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Beskrivelse: Host: Mouse, Isotype: IgG1

UOM: 1 * 1 Each

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Varenummer: (ENZOBMLKI3400020)

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Beskrivelse: Assay buffer from the 20S Proteasome Assay Kit for Drug Discovery.

UOM: 1 * 20 mL

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Varenummer: (ENZOBMLKI5840001)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: HTS mikroplader

UOM: 1 * 1 Each

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Beskrivelse: Potent inhibitor of phosphatidic acid generation

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