PP2 ≥98% (by TLC)
Leverandør: ENZO LIFE SCIENCESSamlet vurdering
Gennemsntilig vurdering
Synonymer:
1-(tert-Butyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Src kinase inhibitor
A potent and selective inhibitor of the Src family tyrosine kinases. Inhibits Lck (IC50=4 nM), Fyn (IC50=5 nM), and Hck (IC50=5 nM). It displays weaker inhibition of EGFR (IC50=480 nM) and no inhibition of ZAP-70 (IC50 100 µM) and JAK2 (IC5050 µM). PP2 is a useful tool for probing the involvement of Src family tyrosine kinases in cellular signaling.
Formel:
C₁₅H₁₆ClN₅ Molekylvægt: 301.8 g/mol |
MDL Number:
MFCD01568210 CAS-nummer: 172889-27-9 |
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