Du Søgte efter: STEMCELL Technologies

Varenummer: (STMC100-0047)

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic positive selection kit using particle release technology

UOM: 1 * 1 Each

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic negative selection kit

Varenummer: (STMC78187.1)

Leverandør: STEMCELL Technologies

Beskrivelse: Fibroblast growth factor acidic (FGF-acidic), also known as FGF-1, is a potent activator of DNA synthesis, cell proliferation, and chemotaxis and is known to play numerous roles in development, regeneration, and angiogenesis (Jaye <i>et al.</i>; Galzie <i>et al.</i>; Presta <i>et al.</i>). FGF-acidic is produced by multiple cell types and is capable of activating all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It is found in large quantities in the brain, but is also expressed in hepatocytes, vascular smooth muscle cells, neurons of the CNS, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF-acidic is secreted as a disulfide-linked homodimer and is stored in complex with heparan sulfate, a requirement for its interaction with FGF receptors (Guerrini <i>et al.</i>; Mohammadi <i>et al.</i>). Internalized FGF-acidic signals through protein kinase C and promotes cell survival by inhibiting p53 and proapoptotic signaling (Bouleau <i>et al.</i>).

UOM: 1 * 1 Each

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Leverandør: STEMCELL Technologies

Beskrivelse: For detection and measurement of mouse interleukin 4.

Leverandør: STEMCELL Technologies

Beskrivelse: Insulin-like growth factor-binding protein 4 (IGFBP-4) inhibits the actions of IGF-I and IGF-II. The distribution of IGFBP-4 in tissues is dependent on its glycosylation state, however it preferentially targets connective tissue (Firth and Baxter; Qin <i>et al.</i>). IGFBP-4 is also produced in liver, adrenal glands, Leydig cells, developing embryos, spinal cord, and thymic cortex. IGFBP-4 inhibits WNT/β-catenin signaling, which downregulates prostate cancer proliferation (Zhu <i>et al.</i>). In vitro studies suggest that IGFBP-4 inhibits proliferation of neuroblastoma and glioma, while promoting bone loss in osteosarcoma and multiple myeloma (Durai <i>et al.</i>).

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic negative selection of rat cells

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Varenummer: (STMC100-1296)

Leverandør: STEMCELL Technologies

Beskrivelse: A member of the SIBLING family of glycoproteins (Rangaswami <i>et al.</i>), Osteopontin (OPN) functions as T-helper 1 cytokine, and plays an important role in cell signaling, migration, and activation (Weber <i>et al.</i>, 2002). Osteopontin has been shown to regulate inflammation both in vitro and <i>in vivo</i> (Agnholt <i>et al.</i>; Kiefer <i>et al.</i>), and has been implicated in the pathophysiology of numerous cancers, including prostate (Thalmann <i>et al.</i>), lung (Chambers <i>et al.</i>), ovarian (Kim <i>et al.</i>), and breast etiologies (Weber <i>et al.</i>, 2015). In humans, OPN is initially secreted as a 317 amino acid protein which is subject to tissue-specific post-translational modifications by glycosylation, phosphorylation, and transglutamination (Kazanecki <i>et al.</i>; Sodek <i>et al.</i>). This protein product contains a His-residue tag at the amino end of the polypeptide chain. For consistency and reproducibility across your applications, Osteopontin from STEMCELL comes lyophilised with ≥92% purity, and endotoxin levels are verified to be ≤1,0 EU/μg protein.

UOM: 1 * 1 Each

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Varenummer: (STMC100-1299)

Leverandør: STEMCELL Technologies

Beskrivelse: Use sclerostin to alter bone remodeling homeostasis, where it inhibits bone formation in vivo and in vitro, likely through Wnt/β-catenin signaling cascades (Ellies <i>et al.</i>; Lin <i>et al.</i>). Sclerostin is a member of the cerberus/DAN family of glycoproteins whose members share a C-terminal cysteine-knot-like (CTCK) domain. Highly expressed in bone and cartilage, as well as in kidney, and liver tissues (Weivoda <i>et al.</i>), this osteoclast-derived BMP antagonist binds BMP6 and BMP7 with high affinity, and binds BMP2 and BMP4 with a lower affinity (Kusu <i>et al.</i>). Mutations in the SOST gene have been associated with sclerosteosis (Brunkow <i>et al.</i>), van Buchem disease (Staehling-Hampton <i>et al.</i>), and bone dysplasia disorders, characterized by increased bone density. This protein product contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, sclerostin from STEMCELL comes lyophilised with ≥87% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

UOM: 1 * 1 Each

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Varenummer: (STMC100-1329)

Leverandør: STEMCELL Technologies

Beskrivelse: Modulate prostaglandin metabolism with 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH catalyses the reversible oxidation of the 15-hydroxyl group in prostaglandins, resulting in inactivated metabolites (Ensor and Tai), it can act on a variety of prostaglandins as substrates in a NAD+ dependent manner (Cho <i>et al.</i>). As prostaglandins can have a range of effects on cellular processes, 15-PGDH is of considerable importance in drug development. In vitro and <i>in vivo</i> studies suggest 15-PGDH has tumor suppressive activity and is downregulated in certain cancers (Na <i>et al.</i>).15-PGDH belongs to the short-chain dehydrogenases/reductases (SDR) family; its primary structure indicates 20% homology with other SDRs, with some conserved amino acid residues (Krook <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apo M from STEMCELL comes lyophilised with ≥89% purity.

UOM: 1 * 1 Each

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Varenummer: (STMC100-1333)

Leverandør: STEMCELL Technologies

Beskrivelse: Fetuin B is thought to have functions in female fertility, metabolism, and liver disease. A protease inhibitor belonging to the fetuin family of proteins, within the cystatin superfamily, fetuin b’s structure includes two cystatin domains (CY1 and CY2) connected by a linker, with a CPDCP-trunk and a C-terminal region (CTR) (Cuppari <i>et al.</i>). This plasma protein originates in the liver (Denecke <i>et al.</i>) and acts to inhibit the activity of ovastacin, a metalloprotease that causes the zona pellucida to harden, leading to female infertility (Karmilin <i>et al.</i>). Fetuin B has also been reported to increase apoptosis, and inhibit migration and invasion of prostate cancer cells, in in vitro and <i>in vivo</i> settings (Zhan <i>et al.</i>). Elevated serum fetuin B has been linked to non-alcoholic fatty liver disease (NAFLD) (Zhu <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilised with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

UOM: 1 * 1 Each

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Varenummer: (STMC78182.1)

Leverandør: STEMCELL Technologies

Beskrivelse: Fibroblast growth factor 5 (FGF-5) is a secreted, heparin-binding member of the FGF subfamily. FGFs possess broad mitogenic and cell survival activities and are expressed during embryonic development. FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous systems, and hair follicles. FGF-5 promotes cell differentiation and proliferation by binding FGF receptor 1 and FGF receptor 2 (FGFR1 and FGFR2, respectively). FGF-5 plays an important regulatory role in skeletal muscle development. FGF-5 has also been identified in neurons of the limbic system, especially those of the olfactory bulb and pyramidal cells of the hippocampus (Haub and Goldfarb).

UOM: 1 * 1 Each

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of CD4+ T cells directly from whole blood

Varenummer: (STMC100-0674)

Leverandør: STEMCELL Technologies

Beskrivelse: The RSV (HLA Class I Control) peptide pool is a lyophilised mixture of 28 peptides from respiratory syncytial virus (RSV). The pool consists of defined HLA class I-restricted T cell epitopes, and can be used as an antigen-specific positive control to stimulate T cells.

UOM: 1 * 1 Each

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Leverandør: STEMCELL Technologies

Beskrivelse: Chimeric mouse (V), human (C) monoclonal IgG antibody against SARS-CoV, SARS-CoV-2 (2019-nCoV) S protein (HEK293-expressed recombinant).

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched human CD8+ T cells.

Varenummer: (STMC100-0188)

Leverandør: STEMCELL Technologies

Beskrivelse: PBS buffer containing EDTA.

UOM: 1 * 9 L

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