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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched human CD8+ T cells.

Varenummer: (STMC07923)

Leverandør: STEMCELL Technologies

Beskrivelse: 1 U/ml dispase in DMEM/F-12.

UOM: 1 * 100 mL

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched mouse NK cells

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched rat CD8+ T cells

Leverandør: STEMCELL Technologies

Beskrivelse: 15 ml centrifuge tube with an insert for density gradient centrifugation

Varenummer: (STMC19771)

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched mouse mesenchymal stem/progenitor cells

UOM: 1 * 1 Each

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Varenummer: (STMC19664)

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of B-CLL cells directly from whole blood

UOM: 1 * 1 Each

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunodensity isolation of untouched T cells for HLA analysis.

Leverandør: STEMCELL Technologies

Beskrivelse: Complete kit for CD34+ cells from cord blood.

Varenummer: (STMC03120)

Leverandør: STEMCELL Technologies

Beskrivelse: Base methylcellulose medium for <i>in vitro</i> differentiation of mouse ES or iPS cells to hematopoietic or endothelial progenitor cells.

UOM: 1 * 40 mL

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Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic negative selection of human pan-B cells

Leverandør: STEMCELL Technologies

Beskrivelse: Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes IL-17B through IL-17F. It is a potent pro-inflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-κB, MAPK, and C/EBP pathways (Gaffen). IL-17A is produced by Th17 cells, CD8+ T cells, γ/δ T cells, natural killer (NK) T cells, B cells, innate lymphoid cells, and mesenchymal stromal cells (MSCs) (Cua and Tato; Gaffen; Mojsilović <i>et al.</i>). IL-17A mediates protection against extracellular pathogens, and together with IL-22 stimulates production of antimicrobial peptides. It induces granulopoiesis factors and neutrophil-specific chemokines. Together with tumor necrosis factor alpha (TNF-α), IL-17A induces a sustained neutrophil recruitment during inflammation (Cua and Tato). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of fibroblast colony-forming units (CFU-F), as well as the proliferation of marrow-derived MSCs. It enhances osteogenic differentiation, and inhibits adipocyte differentiation and chondrogenesis (Mojsilović <i>et al.</i>).

Leverandør: STEMCELL Technologies

Beskrivelse: Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan <i>et al.</i>). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. Mice deficient in IL-1β do not show phenotypical differences from wild-type mice; however, they have a reduced response to inflammation, suggesting that IL-1β plays a key role in inflammatory diseases (Dinarello).

Leverandør: STEMCELL Technologies

Beskrivelse: RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall <i>et al.</i>). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv <i>et al.</i>; Maghazachi <i>et al.</i>). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi <i>et al.</i>).

Leverandør: STEMCELL Technologies

Beskrivelse: Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew <i>et al.</i>). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera <i>et al.</i>). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan <i>et al.</i>).

Leverandør: STEMCELL Technologies

Beskrivelse: Animal component-free collagenase for the digestion of native collagen fibrils.