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MCI GEL® CHP20P 75 - 150 μm, Supelco®

Leverandør: Merck

Beskrivelse: MCI GEL® CHP20P is a highly porous styrene-divinylbenzene polymer resin used as column packing material.

Anti-ATG12 Rabbit Polyclonal Antibody

Varenummer: (PRSI4423)

Leverandør: ProSci Inc.

Beskrivelse: ATG12 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG12, another member of the autophagy protein family, forms a conjugate with ATG5; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist.

UOM: 1 * 1 Each

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Kieselgel 1 - 4 mm tørremiddel, with moisture indicator (brown gel), Supelco®

Leverandør: Merck

Beskrivelse: Kieselgel 1 - 4 mm drying agent, with moisture indicator (brown gel), Supelco®

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Amino-functionalized silica gel, spherical 40-75 μm particle size, Supelco®

Leverandør: Merck

Beskrivelse: Amino-functionalized silica gel, spherical 40-75 μm particle size, Supelco®

Anti-AKT1 Rabbit Polyclonal Antibody

Varenummer: (PRSI3519)

Leverandør: ProSci Inc.

Beskrivelse: Akt1 Antibody: Akt1, initially identified as the cellular homolog to the retro-viral oncogene v-Akt, is part of the phosphatidyl 3'-kinase (PI3K)-Akt signaling pathway that is activated by diverse cellular stimuli and regulates critical cellular functions such as cell growth, proliferation, and survival. Following phosphorylation of the second messenger PIP2 by PI3K, Akt1 translocates to the cell membrane where it is activated by phosphoinositide-dependent kinase (PDK) 1 and PDK2. The active Akt1 is then able to phosphorylate and activate its substrates, including those that are important for cell proliferation and survival such as TOR and the Bcl-2 homolog Bad. Negative regulation of the PI3K-Akt signaling pathway is mainly accomplished by the lipid phosphatase activity of PTEN which catalyzes the conversion of PIP3 to PIP2, thereby preventing the activation of Akt1. Inactivation of this gene often results in excessive Akt1 activity, often leading to the formation of malignant tumors.

UOM: 1 * 1 Each

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