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Anti-SETD7 Rabbit Polyclonal Antibody

Varenummer: (PRSI56-134)

Leverandør: ProSci Inc.

Beskrivelse: Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function; rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage.

UOM: 1 * 400 µl

New Product Tilbud

N/A Each

Human recombinant UBE2G2 (from E. coli)

Varenummer: (PRSI91-976)

Leverandør: ProSci Inc.

Beskrivelse: Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.

UOM: 1 * 1 Each

Tilbud

N/A Each

Roller bottles, Nunc™ InVitro™

Varenummer: (734-2394)

Leverandør: Thermo Fisher Scientific

Beskrivelse: PETG, sterile.

UOM: 1 * 20 Items

Tilbud

N/A Each

2-Bromethylamin hydrobromid til syntese, Sigma-Aldrich®

Leverandør: Merck

Beskrivelse: 2-Bromethylamin hydrobromid til syntese, Sigma-Aldrich®

MSDS

Diethylamin hydrobromid zS, Sigma-Aldrich®

Leverandør: Merck

Beskrivelse: Diethylamin hydrobromid zS, Sigma-Aldrich®

MSDS

Biotin ethylenediamine hydrobromide ≥95% (by TLC), Sigma-Aldrich®

Varenummer: (B9181-25MG)

Leverandør: SIGMA ALDRICH MICROSCOPY

Beskrivelse: Biotin ethylenediamine hydrobromide. ≥95% (TLC), solid ((3aS,4S,6aR)-N-(2-Aminoethyl)hexahydro- 2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide; N-(2-Aminoethyl)biotinamide hydrobromide)

UOM: 1 * 25 mg

Tilbud