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MMP-13 inhibitor ≥99% (by HPLC)

Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Potent MMP-13 inhibitor.

New Product

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CL-82198 (MMP-13 inhibitor) ≥98% (by TLC)

Leverandør: ENZO LIFE SCIENCES
Beskrivelse: A novel and selective inhibitor of MMP-13 (89% at 33 µM). Acts via binding to the S1' pocket of MMP-13 without metal chelation.

New Product

Image Unavailable-ENZOBMLAK4120001

Matrix Metalloproteinase-13 (MMP-13) colorimetric drug discovery kit

Varenummer: (ENZOBMLAK4120001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: A QuantiZyme™ Assay System. The MMP-13 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-13 (MMP-13, collagenase-3) using a thiopeptide as a chromogenic substrate.
UOM: 1 * 1 Each

New Product


Image Unavailable-ENZOBMLAK4130001

Matrix Metalloproteinase-13 (MMP-13) fluorometric drug discovery kit

Varenummer: (ENZOBMLAK4130001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: A QuantiZyme™ Assay System. The MMP-13 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-13 (MMP-13, collagenase-3) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.
UOM: 1 * 1 Each

New Product


Image Unavailable-ENZOBMLP1450001

Cathepsin D & E substrate (fluorogenic)

Varenummer: (ENZOBMLP1450001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Quenched fluorogenic substrate for cathepsin D (kcat/Km=1,09×10 M-1s-1) and cathepsin E (kcat/Km=1,56×10 M-1s-1). Mca fluorescence is quenched by the Dnp group until cleavage separates them. Activity of the two enzymes on this substrate can be distinguished by the use of Ascaris pepsin inhibitor, which inhibits cathepsin E, but not cathepsin D. This substrate is also cleaved by MMP-2, MMP-3, MMP-9, but not MMP-1 nor MMP-13. This substrate is useful for inhibitor screening and kinetic analysis. Ex.: 320-340 nm, Em.: 393-420 nm. Mca-Pro-Leu-OH (BML-P127) can be used to calibrate for Mca fluorescence.
UOM: 1 * 1 mg

New Product


Product Image-ENZOBMLP1320500

TACE substrate (fluorogenic)

Varenummer: (ENZOBMLP1320500)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).
UOM: 1 * 0,5 mg

New Product


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ADAM Substrate

Varenummer: (ENZOBMLP2350001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Fluorogenic substrate for ADAM8 (kcat/Km = 1,0×105 M-1s-1), ADAM10 (6,2×103), ADAM12 (2,8×105), TACE (TNF-α converting enzyme, ADAM17) (4,3×105), and likely other ADAMs, especially those that cleave TNF-α type sequences. Also efficiently cleaved by MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-13, and MMP-14. FAM fluorescence is quenched by the Dabcyl group until cleavage separates them. Ex.: 485 nm, Em.: 530 nm. This substrate is useful for inhibitor screening and kinetic analysis.
UOM: 1 * 1 mg

New Product


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MMP-9/MMP-13 inhibitor I ≥95% (by HPLC), Millipore®

Varenummer: (444252-1)
Leverandør: Merck Millipore (Calbiochem‎)
Beskrivelse: A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀=900 pM) and MMP-13 (IC₅₀=900 pM).
UOM: 1 * 1 mg
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Human recombinant TIMP2 (from cells)

Varenummer: (PRSI91-415)
Leverandør: ProSci Inc.
Beskrivelse: Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
UOM: 1 * 1 Each
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Mouse recombinant TIMP1

Varenummer: (PRSI92-603)
Leverandør: ProSci Inc.
Beskrivelse: Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.
UOM: 1 * 1 Each
Image Unavailable-PRSI91-412

Human recombinant TIMP1 (from cells)

Varenummer: (PRSI91-412)
Leverandør: ProSci Inc.
Beskrivelse: Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.
UOM: 1 * 1 Each
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MMP-​9 inhibitor I ≥97% (by HPLC)

Varenummer: (ENZOENZCHM1330001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Cell-permeable, potent, selective, and reversible MMP-9 inhibitor.
UOM: 1 * 1 mg

New Product


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MMP-3 inhibitor ≥95% (by HPLC)

Varenummer: (ENZOALX260165M005)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: Inhibitor of matrix metalloproteinase 3 (MMP-3) (IC50=5µM).
UOM: 1 * 5 mg

New Product


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MMP inhibitor profiling kit

Varenummer: (ENZOBMLAK3080001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: The MMP inhibitor profiling kit, fluorometric RED is a complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes, using a quenched fluorogenic substrate OMNIMMP® RED.
UOM: 1 * 1 Each

New Product


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MMP Inhibitor profiling kit, fluorometric

Varenummer: (ENZOBMLAK0160001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: A QUANTIZYME® Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
UOM: 1 * 1 Each

New Product


Image Unavailable-ENZOBMLAK0150001

MMP Inhibitor profiling kit, colorimetric

Varenummer: (ENZOBMLAK0150001)
Leverandør: ENZO LIFE SCIENCES
Beskrivelse: A QUANTIZYME® Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a chromogenic substrate1,2 detected at 412 nm. Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
UOM: 1 * 1 Each

New Product


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