Anti-Nestin Mouse Monoclonal Antibody [clone: 10C2] (Alexa Fluor® 488)

Leverandør: STEMCELL Technologies
Ratings: Ingen bedømmelse

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Anti-Nestin Mouse Monoclonal Antibody [clone: 10C2] (Alexa Fluor® 488)
Antistoffer
Mouse monoclonal IgG1 antibody against human, cynomolgus nestin, Alexa Fluor® 488-conjugated.

  • Neural cells Psc derived
  • Neural stem
  • Progenitor cells
  • Neurons

The 10C2 antibody reacts with human nestin, a class VI intermediate filament (IF) protein expressed by embryonic neuroepithelial stem cells in the developing nervous system and by pancreatic islet and mesenchymal progenitor cells. Nestin expression is also observed in glioblastomas and many primary and metastatic melanomas and it is a useful angiogenic marker to evaluate neovascularity of endothelial cells in tumors. Nestin is required for the survival and renewal of neural progenitor cells and plays roles in cellular remodeling by forming heterodimers with vimentin or alpha-internexin, a process that appears to be tightly regulated by phosphorylation. Nestin localizes to the growth cones during axon elongation in differentiating neurons and may play a role in growth cone guidance. Nestin expression is down-regulated during differentiation, typically disappearing by embryonic stage E18. The 10C2 antibody reportedly cross-reacts weakly with monkey nestin but not rodent nestin. A doublet band of ~220 - 250 kDa is observed on western blots with this antibody.

Advarsel: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: Nestin
Clonality: Monoclonal
Clone: 10C2
Conjugation: Alexa Fluor® 488
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Cynomolgus monkey, Human
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