Anti-OCT4 (OCT3) Mouse Monoclonal Antibody [clone: 3A2A20]

Leverandør: STEMCELL Technologies
Ratings: Ingen bedømmelse

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60093 60093.1
STMC60093EA 3515 DKK
STMC60093 STMC60093.1
Anti-OCT4 (OCT3) Mouse Monoclonal Antibody [clone: 3A2A20]
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Mouse monoclonal IgG2b antibody against human OCT4 (OCT3), unconjugated.

  • Pluripotent stem cells

This monoclonal antibody reacts with human octamer-binding transcription factor 4 (OCT4), also known as OCT3 and OCT3/4, an ~40 kDa homeodomain transcription factor belonging to the POU family, which is expressed in undifferentiated human embryonic stem (ES), induced pluripotent stem (iPS), embryonal carcinoma (EC), and embryonic germ (EG) cells. OCT4 binds to the octamer motif 5'-ATTTGCAT-3' and plays a key role in maintaining cells in a pluripotent state by interacting with other transcription factors such as SOX2 to regulate the expression of several genes including FBX15, FGF-4, REX1, SOX2, and osteopontin. OCT4 level is down-regulated during differentiation and it has thus emerged as a useful marker of pluripotency in stem cells, as well as a marker for certain human malignant germ cell tumours. Expression of OCT4 together with other transcription factors has been used to reprogram somatic cells into iPS cells. Multiple isoforms of OCT4 have been observed and in humans at least two are functionally active.

Advarsel: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: OCT4 (OCT3)
Clonality: Monoclonal
Clone: 3A2A20
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
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