Anti-CD40 Mouse Monoclonal Antibody [clone: 5C3] (APC)

Leverandør: STEMCELL Technologies
Ratings: Ingen bedømmelse

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60113AZ 60113AZ.1
STMC60113AZEA 3414 DKK
STMC60113AZ STMC60113AZ.1
Anti-CD40 Mouse Monoclonal Antibody [clone: 5C3] (APC)
Antistoffer
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD40, APC-conjugated.

  • B cells

The 5C3 antibody reacts with CD40, a 45 - 50 kDa type I transmembrane glycoprotein that is a member of the tumor necrosis factor receptor (TNFR) superfamily. CD40 plays an important role in B cell development and is also involved in the process of B cell selection in germinal centers. It facilitates T cell-B cell interactions for co-stimulation and immune regulation through engagement with CD154 (gp39), the CD40 ligand expressed on T cells. In the presence of IL-4, or other stimuli, CD40 promotes B cell proliferation, induces immunoglobulin- (Ig) isotype class switching and rescues B cells from surface Ig-induced apoptosis. CD40 is expressed on the surface of B cells, follicular dendritic cells, macrophages, fibroblasts, keratinocytes, endothelial cells, basal epithelial cells, CD34+ hematopoietic progenitor cells, and primary carcinomas. It is expressed at low levels, or not at all, on plasma cells. The 5C3 antibody has been used for the activation of B cells in in vitro functional assays or for the induction of B cell proliferation.

Advarsel: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD40
Clonality: Monoclonal
Clone: 5C3
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Chimpanzee, Cynomolgus monkey, Human, Rhesus monkey, Squirrel monkey
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