Anti-CD45RA Hamster Monoclonal Antibody [clone: HI100] (Biotinilated)

Leverandør: STEMCELL Technologies
Ratings: Ingen bedømmelse

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100-0321 100-0322
STMC100-0321EA 0 DKK
STMC100-0321 STMC100-0322
Anti-CD45RA Hamster Monoclonal Antibody [clone: HI100] (Biotinilated)
Antistoffer
Hamster (Armenian) monoclonal IgG, antibody against mouse, CD152 (CTLA-4), PE-conjugated.

  • Granulocytes
  • Subsets
  • Hematopoietic stem
  • Progenitor cells
  • Leukocytes
  • Lymphocytes

The HI100 antibody reacts with an extracellular epitope on the CD45RA isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5, and 6 that encode the extracellular RA, RB, and RC polypeptides of CD45 gives rise to several isoforms with molecular masses of 180 - 240 kDa. Excision of exon 4 generates the ~220-kDa CD45RA isoform, which is expressed on naïve T cells, subsets of B cells and monocytes, and medullary thymocytes. CD45RA functions to enhance signaling through both the T cell receptor and B cell receptor. The HI100 antibody is commonly used in combination with antibodies against the CD45RO isoform to discern naïve and memory T cells and is useful for identifying the suppressor/inducer subset of CD4+ lymphocytes. The proportion of CD45RA+ T cells typically decreases with age.

Advarsel: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD45RA
Clonality: Monoclonal
Clone: HI100
Conjugation: Biotin
Epitope:
Host: Hamster
Isotype:
Reactivity: Chimpanzee, Human
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