Anti-cFOS Sheep Polyclonal Antibody

Leverandør: Biosensis
Ratings: Ingen bedømmelse

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BSENS-033-500EA 2330 DKK
BSENS-033-500
Anti-cFOS Sheep Polyclonal Antibody
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FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily. SIMILARITY: Contains 1 bZIP domain

This antiserum shows a high level of specificity for cFOS confirmed by immunohistochemistry.

Application Information:
IHC: Use at an amount of 10 µg/mL with an incubation time of 1-3 days at 4ºC. This antiserum works in paraffin and 4% PFA fixed frozen sections. Penetration is the key to success. Over-fixed tissue is problematic. Not recommended for western blotting applications. Mouse monoclonal antibody BSENM-1752-100 or rabbit polyclonal antibody BSENR-1751-50 are excellent alternatives for western blotting. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: cFOS
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: aa 2-17 c-Fos
Host: Sheep
Isotype: IgG
Reactivity: Rat, Rabbit, Hamster
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