Du Søgte efter: ProSci Inc.

Varenummer: (PRSI5379P)

Leverandør: ProSci Inc.

Beskrivelse: JMJD4 peptide is used for blocking the activity of JMJD4 antibody.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI96-031)

Leverandør: ProSci Inc.

Beskrivelse: ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI96-537)

Leverandør: ProSci Inc.

Beskrivelse: Human recombinant MMP1 (from HEK293 cells)

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI3295P)

Leverandør: ProSci Inc.

Beskrivelse: SARM peptide is used for blocking the activity of SARM antibody.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI91-851)

Leverandør: ProSci Inc.

Beskrivelse: Human BTN3A3, also known as butyrophilin subfamily 3 member A3 and BTF3, is a Single-pass type I membrane protein which belongs to the immunoglobulin superfamily and BTN/MOG family. The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin domains and an intracellular B30.2 (PRYSPRY) domain. It can be detected in peripheral blood mononuclear cells, T-cells l, spleen and lymphocytes. BTN3A3 plays a role in T-cell responses in the adaptive immune response.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI91-289)

Leverandør: ProSci Inc.

Beskrivelse: SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI90-409)

Leverandør: ProSci Inc.

Beskrivelse: Human CD137 (4-1BB) is a costimulatory molecule of the tumour necrosis factor (TNF) receptor superfamily. The glycoprotein 4-1BB is expressed mainly on activated CD4 + and CD8 + T cells and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumour receptor-associated factors (TRAF), the adaptor protein and mediates downstream signalling events including the activation of NF-kappaB and cytokine production. 4-1BB signalling either by binding to 4-1BBL or by antibody ligation delivers signals for T cell activation and growth as well as monocyte proliferation and B cell survival, and plays a important role in the amplification of T cell-mediated immune responses. In contrast, it can also enhance activation-induced T cell apoptosis when triggered by engagement of the TCR/CD3 complex. In addition, the 4-1BB/4-1BBL costimulatory pathway has been shown to augment secondary CTL responses to several viruses and increase antitumour immunity. 4-1BB is therefore a promising candidate for immunotherapy of human cancer.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI92-677)

Leverandør: ProSci Inc.

Beskrivelse: Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Previous studies reported that granzyme D is developmentally regulated during pregnancy together with granzymes E, F, and G in granulated metrial gland cells and is upregulated by IL-2 and IL-15. Granzyme D was also suggested to have a role in stromal cell-lymphocyte interactions.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI96-755)

Leverandør: ProSci Inc.

Beskrivelse: Human recombinant transferrin (from HEK293 cells)

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI40-566)

Leverandør: ProSci Inc.

Beskrivelse: NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Manufactured using all non-animal reagents.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI92-195)

Leverandør: ProSci Inc.

Beskrivelse: NECAP2 belongs to the NECAP family. The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Adaptin ear-binding coat-associated protein 2 can interacts with AP1G1 and AP2A1 components of the adapter protein complex AP-1 and AP-2. It also interacts with the GAE domain proteins GGA1, GGA2 and GGA3.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI96-109)

Leverandør: ProSci Inc.

Beskrivelse: Leukocyte differentiation antigen CD84 is also known as SLAM family member 5 (SLAMF5), which belongs to immunoglobulin (Ig) superfamily. CD84 / SLAMF5 contains one Ig-like C2-type (immunoglobulin-like) domain. CD84 plays a role as adhesion receptor functioning by homophilic interactions and by clustering. CD84 / SLAMF5 increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI92-385)

Leverandør: ProSci Inc.

Beskrivelse: CUB domain-containing protein 1(CDCP1) is a transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsinor EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI6133P)

Leverandør: ProSci Inc.

Beskrivelse: ZMYM1 peptide is used for blocking the activity of ZMYM1 antibody.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI91-385)

Leverandør: ProSci Inc.

Beskrivelse: Zinc- alpha-2-Glycoprotein (AZGP1) can be found in blood plasma, seminal plasma, urine, sweat, saliva, liver, and epithelial cells of various human glands. AZGP1 has been proposed in the regulation of body weight, and the melanin production by normal and malignant melanocytes. AZGP1 stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. AZGP1 has been reported to stimulate lipid breakdown and may have an important role in lipid homeostasis. Mature human AZGP1 consists of one MHC class I antigen region and a C2-type Ig-like domain. AZGP1 has two alternate splice forms, one shows a 66 amino acids substitution for the C-terminal 30 amino acids, the other one shows a nine Lys substitution for amino acid 151-298.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI7227P)

Leverandør: ProSci Inc.

Beskrivelse: 15 amino acids near the center of human CCL4.

UOM: 1 * 1 Each

Tilbud