Du Søgte efter: ENZO LIFE SCIENCES

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Beskrivelse: Hsp47, also known as colligin and gp46, is an ER-resident collagen-specific stress glycoprotein involved in the synthesis and assembly of varoius collagens as a molecular chaperone.

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Varenummer: (ENZOADISPA1101E)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: Hsp 110 belongs to a family of large stress proteins known as the Hsp110/SSE family, the mostly overlooked relatives of the well studied Hsp70 family. Members of this group, while significantly larger and containing sequences not present in the Hsp70 family, share 30-33% amino acid identity with members of the Hsp70 family, mostly in the conserved ATP-binding domain. Presently, all identified members of the Hsp70-like sequences belong to either the Hsp70 family or the Hsp110/SSE family. Hsp110 appears to be a normal constituent of mammalian cells with highest expression in the brain, and its induction by heat shock strongly correlates with cellular thermotolerance. Hsp110 may contribute to RNA stability, and its capacity to bind peptide has made Hsp110 a promising immunoadjuvant in anti-tumor vaccine development.

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Leverandør: ENZO LIFE SCIENCES

Beskrivelse: Ubiquitin (Ub) plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The protein to be degraded is conjugated to Ub and the ubiquinated protein is then selectively degraded by the 26S complex, a multicatalytic cytosolic and nuclear protease. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

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Varenummer: (ENZOADISPA450E)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: Hsp40/Hdj1 is a cytosolic co-chaperone belonging to the class DnaJ, named after its homolog in <i>E. coli</i>. Hsp40 functions in protein folding by binding nascent peptides and unfolded substrates and facilitating substrate interaction with Hsp70.

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Varenummer: (ENZOADI905730100)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

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Varenummer: (ENZOADI905749100)

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Beskrivelse: The cannabinoid receptors CB1 and CB2 are GPCRs named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). In addition to Delta9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands (e.g. anandamide), and signal via Gi/o alpha subunits to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.

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Varenummer: (ENZOADI905733100)

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Beskrivelse: Actin is one of the major proteins of the cytoskeleton. It regulates contractile potential in muscle tissues and helps to control the shape as well as the motility of non-muscle cells. Actin is expressed in all eukaryotic cells. In higher eukaryotes, there are six isoforms of actin.

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Varenummer: (ENZOADI905708100)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: The cannabinoid receptors CB1 and CB2 are GPCRs named for their signaling function in response to cannabinoid drugs such as Delta9-tetrahydrocannabinol (Delta9-THC). In addition to Delta9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands (e.g. anandamide), and signal via Gi/o alpha subunits to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.

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Varenummer: (ENZOADI905684100)

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Beskrivelse: Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.

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Varenummer: (ENZOALX804826C100)

Leverandør: ENZO LIFE SCIENCES

Beskrivelse: Host: Rat, Isotype: IgG2a

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Varenummer: (ENZOALX804830C100)

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Beskrivelse: Host: Rat, Isotype: IgG1

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Varenummer: (ENZOALX804502C100)

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Beskrivelse: Host: Mouse, Isotype: IgG1

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Beskrivelse: TRIP-Br1 (SEI-1) functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 is defined as an oncogene.

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Varenummer: (ENZOALX804821C100)

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Beskrivelse: Host: Mouse, Isotype: IgG1

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Varenummer: (ENZOBMLPW92500025)

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Beskrivelse: Host: Mouse, Isotype: IgG1

UOM: 1 * 25 µl

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Varenummer: (ENZOENZABS2230100)

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Beskrivelse: Recommended Applications: Flow Cytometry, ICC, WB

Species reactivity: Human, Mouse

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