Du Søgte efter: Chiral+Technologies

Leverandør: STEMCELL Technologies

Beskrivelse: Interleukin 3 (IL-3) is a species-specific pleiotropic cytokine that promotes the survival and proliferation of pluripotent hematopoietic stem cells and lineage-committed progenitor cells and their differentiation into mature cells of most lineages, including basophils, neutrophils, eosinophils, macrophages, dendritic cells, erythrocytes, and megakaryocytes (Yang <i>et al.</i>; Dorssers <i>et al.</i>; Broughton <i>et al.</i>). IL-3 is produced by activated T cells and has a physiological role in inflammation and allergies by promoting the secretion of inflammatory mediators such as histamine, IL-4, and IL-6 by basophils and eosinophils (Broughton <i>et al.</i>). The IL-3 receptor consists of a unique alpha subunit (CD123) and a beta common subunit (βc or CD131) that is shared with the receptors for IL-5 and GM-CSF, and is the principal signal transduction subunit for these cytokines. IL-3 binding to the heterodimeric receptor activates JAK/STAT, MAPK, and PI3K signaling pathways (Woodcock <i>et al.</i>).

Leverandør: STEMCELL Technologies

Beskrivelse: Sonic hedgehog (Shh) is a member of the Hedgehog family of secreted signaling proteins that has a prominent role in patterning during early mammalian development (Ho and Scott). It is expressed during early embryogenesis in a variety of tissues (Finco <i>et al.</i>). During patterning of the central nervous system, Shh directly acts on cells to specify neural cell fates, regulates proliferation and survival of oligodendrocytes precursors and neural crest cells and stimulates proliferation, differentiation and axon growth (Ho and Scott; Martí). Shh also regulates T cell differentiation and activation (Crompton <i>et al.</i>). Recombinant human Shh (C24II; rhShh) is a fully biologically active molecule.

Leverandør: STEMCELL Technologies

Beskrivelse: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Mouse G-CSF was first purified from cultures of the WEHI-3B myelomonocytic leukemia cell line as the inducer of the terminal differentiation of WEHI-3B and other myeloid leukemia cell lines (Nicola <i>et al.</i>). It was later cloned in monkey COS cells from a cDNA library prepared with mRNA derived from mouse fibrosarcoma NFSA cells that produce G-CSF constitutively (Tsuchiya <i>et al.</i>). Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.

Leverandør: STEMCELL Technologies

Beskrivelse: Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that activates NF-kB, MAPK, and PI3K/AKT pathways. Activated T cells and macrophages are the primary producers of TNF-α in response to inflammation and infectious conditions. Many other cell types have been shown to produce TNF-α, among them B cells, NK cells, mast cells, neutrophils, dendritic cells, microglia, endothelial cells, smooth muscle cells, cardiomyocytes, and fibroblasts. TNF-α has cytotoxic effects on cancer cells in vitro by stimulating anti-tumor immuno- suppressive responses. TNF-α stimulates expression of E- and P-selectins, thus facilitating adhesion of neutrophils, monocytes, and memory T cells to activated platelets and endothelial cells (Zelová and Hosek). Other effects of TNF-α include vasodilatation and edema formation.

Varenummer: (STMC10981)

Leverandør: STEMCELL Technologies

Beskrivelse: Serum-free and xeno-free medium for the expansion of human T cells.

UOM: 1 * 500 mL

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Varenummer: (STMC36750)

Leverandør: STEMCELL Technologies

Beskrivelse: RPMI 1640 medium.

UOM: 1 * 500 mL

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Varenummer: (STMC19849)

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic isolation of untouched human cells

UOM: 1 * 1 Each

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Varenummer: (STMC05859)

Leverandør: STEMCELL Technologies

Beskrivelse: Animal component-free medium for freezing ES and iPS cells as single cells.

UOM: 1 * 50 mL

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Varenummer: (STMC05701)

Leverandør: STEMCELL Technologies

Beskrivelse: Supplement for expansion of mouse and rat neural stem and progenitor cells.

UOM: 1 * 50 mL

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Varenummer: (STMC04445)

Leverandør: STEMCELL Technologies

Beskrivelse: Pre-aliquoted methylcellulose-based medium with recombinant cytokines for human cells. 24x3ml vials.

UOM: 1 * 72 mL

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Varenummer: (STMC36450)

Leverandør: STEMCELL Technologies

Beskrivelse: Minimum Essential Medium Eagle - Alpha modification (Alpha MEM) with nucleosides.

UOM: 1 * 500 mL

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Varenummer: (STMC04230)

Leverandør: STEMCELL Technologies

Beskrivelse: Methylcellulose-based medium without cytokines for human cells.

UOM: 1 * 80 mL

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Varenummer: (STMC07901)

Leverandør: STEMCELL Technologies

Beskrivelse: Enzymatic cell dissociation reagent.

UOM: 1 * 500 mL

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Leverandør: STEMCELL Technologies

Beskrivelse: Fibroblast growth factor 7 (FGF-7) is a member of the FGF family, and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch and Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation, migration, and differentiation of these cells, and also participates in epithelial protection and repair both in vitro and <i>in vivo</i> (Finch and Rubin; Werner). In contrast, FGF-7 is produced solely by cells of mesenchymal origin, and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin <i>et al.</i>). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag <i>et al.</i>) and to induce autophagy in human keratinocytes (Belleudi <i>et al.</i>). Additionally, FGF-7 has a role in pluripotent stem cell differentiation to endodermal pancreatic-like insulin-producing cells and thymic epithelial cells (Inami <i>et al.</i>; Niu <i>et al.</i>).

Leverandør: STEMCELL Technologies

Beskrivelse: Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines. It binds to the specific α receptor, which in turn recruits the common β receptor that initiates signaling via JAK/STAT and MAPK pathways. IL-5 is produced by Th2 cells, eosinophils, activated mast cells, and ILC2 cells. IL-5 affects the differentiation, activation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity. Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Shearer).

Leverandør: STEMCELL Technologies

Beskrivelse: Mouse monoclonal IgG1 antibody against mouse, rat, guinea pig CD90/CD90.1, Alexa Fluor® 488-conjugated.