Du Søgte efter: Chiral+Technologies

Varenummer: (STMC100-1395)

Leverandør: STEMCELL Technologies

Beskrivelse: Stimulating T cells with HPV16 (E6) Peptide Pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (E6) Peptide Pool is a lyophilised mixture of 37 peptides from the E6 protein of human papillomavirus type 16 (HPV16). The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 158 on protein E6. E6 binds to the tumor suppressor protein p53 and stimulates its degradation (Scheffner <i>et al.</i>; Werness <i>et al.</i> ), which is thought to cause an increase in spontaneous mutagenesis in host cells (Havre <i>et al.</i>). E6 together with E7 demonstrated the ability to immortalize human keratinocytes in vitro, which likely has significance for HPVs oncogenic potential (Hawley-Nelson <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 YE

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (STMC100-1299)

Leverandør: STEMCELL Technologies

Beskrivelse: Use sclerostin to alter bone remodeling homeostasis, where it inhibits bone formation in vivo and in vitro, likely through Wnt/β-catenin signaling cascades (Ellies <i>et al.</i>; Lin <i>et al.</i>). Sclerostin is a member of the cerberus/DAN family of glycoproteins whose members share a C-terminal cysteine-knot-like (CTCK) domain. Highly expressed in bone and cartilage, as well as in kidney, and liver tissues (Weivoda <i>et al.</i>), this osteoclast-derived BMP antagonist binds BMP6 and BMP7 with high affinity, and binds BMP2 and BMP4 with a lower affinity (Kusu <i>et al.</i>). Mutations in the SOST gene have been associated with sclerosteosis (Brunkow <i>et al.</i>), van Buchem disease (Staehling-Hampton <i>et al.</i>), and bone dysplasia disorders, characterized by increased bone density. This protein product contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, sclerostin from STEMCELL comes lyophilised with ≥87% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (STMC100-1329)

Leverandør: STEMCELL Technologies

Beskrivelse: Modulate prostaglandin metabolism with 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH catalyses the reversible oxidation of the 15-hydroxyl group in prostaglandins, resulting in inactivated metabolites (Ensor and Tai), it can act on a variety of prostaglandins as substrates in a NAD+ dependent manner (Cho <i>et al.</i>). As prostaglandins can have a range of effects on cellular processes, 15-PGDH is of considerable importance in drug development. In vitro and <i>in vivo</i> studies suggest 15-PGDH has tumor suppressive activity and is downregulated in certain cancers (Na <i>et al.</i>).15-PGDH belongs to the short-chain dehydrogenases/reductases (SDR) family; its primary structure indicates 20% homology with other SDRs, with some conserved amino acid residues (Krook <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apo M from STEMCELL comes lyophilised with ≥89% purity.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (STMC100-1333)

Leverandør: STEMCELL Technologies

Beskrivelse: Fetuin B is thought to have functions in female fertility, metabolism, and liver disease. A protease inhibitor belonging to the fetuin family of proteins, within the cystatin superfamily, fetuin b’s structure includes two cystatin domains (CY1 and CY2) connected by a linker, with a CPDCP-trunk and a C-terminal region (CTR) (Cuppari <i>et al.</i>). This plasma protein originates in the liver (Denecke <i>et al.</i>) and acts to inhibit the activity of ovastacin, a metalloprotease that causes the zona pellucida to harden, leading to female infertility (Karmilin <i>et al.</i>). Fetuin B has also been reported to increase apoptosis, and inhibit migration and invasion of prostate cancer cells, in in vitro and <i>in vivo</i> settings (Zhan <i>et al.</i>). Elevated serum fetuin B has been linked to non-alcoholic fatty liver disease (NAFLD) (Zhu <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilised with ≥92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Leverandør: STEMCELL Technologies

Beskrivelse: Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitors (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages <i>in vivo</i>. It has been tested for mobilisation of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>). This product is animal component-free.

New Product

Leverandør: STEMCELL Technologies

Beskrivelse: Insulin-like growth factor-binding protein 4 (IGFBP-4) inhibits the actions of IGF-I and IGF-II. The distribution of IGFBP-4 in tissues is dependent on its glycosylation state, however it preferentially targets connective tissue (Firth and Baxter; Qin <i>et al.</i>). IGFBP-4 is also produced in liver, adrenal glands, Leydig cells, developing embryos, spinal cord, and thymic cortex. IGFBP-4 inhibits WNT/β-catenin signaling, which downregulates prostate cancer proliferation (Zhu <i>et al.</i>). In vitro studies suggest that IGFBP-4 inhibits proliferation of neuroblastoma and glioma, while promoting bone loss in osteosarcoma and multiple myeloma (Durai <i>et al.</i>).

New Product

Leverandør: STEMCELL Technologies

Beskrivelse: Interleukin 6 (IL-6) is a pleiotropic growth factor with the wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Hirano <i>et al.</i>; Mihara <i>et al.</i>; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of JAK/STAT signaling pathway (Mihara <i>et al.</i>; Peters <i>et al.</i>; Tanaka <i>et al.</i>). This product is animal component-free.

New Product

Leverandør: STEMCELL Technologies

Beskrivelse: Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knot (Treanor <i>et al.</i>). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec <i>et al.</i>). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4) out of which GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen and Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both in vivo and in vitro studies and increase their high-affinity dopamine uptake (Granholm <i>et al.</i>; Lin <i>et al.</i>). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi <i>et al.</i>). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor; Catalog #78005), BrainPhys™ Neuronal Medium (Catalog #05790), and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy <i>et al.</i>). This product is animal component-free.

New Product

Leverandør: STEMCELL Technologies

Beskrivelse: Indian hedgehog (IHH) is one of three proteins in the hedgehog family which includes sonic hedgehog and desert hedgehog. Hedgehog proteins are important signaling molecules, acting through patched and smoothened receptors. During embryonic development, they are expressed in the fetal lung, gut, stomach, liver, kidney, and pancreas. IHH is strongly expressed in cartilage and regions of developing bone, and its signaling regulates growth and differentiation of bone tissue (Marigo <i>et al.</i>; Valentini <i>et al.</i>; St-Jacques <i>et al.</i>). IHH is also involved in yolk sac vasculogenesis, indicating a role in the differentiation of epiblast cells into endothelial and red blood cells (Byrd <i>et al.</i>). IHH induces the expression of parathyroid hormone-related peptide (PTHrP), which negatively regulates IHH during chondrocyte differentiation and proliferation (Vortkamp <i>et al.</i>).

New Product

Leverandør: STEMCELL Technologies

Beskrivelse: Immunomagnetic negative selection of rat cells

New Product

Varenummer: (STMC100-0188)

Leverandør: STEMCELL Technologies

Beskrivelse: PBS buffer containing EDTA.

UOM: 1 * 9 L

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (STMC100-1621)

Leverandør: STEMCELL Technologies

Beskrivelse: Rat monoclonal antibody against mouse IL-4, unconjugated.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (STMC100-1629)

Leverandør: STEMCELL Technologies

Beskrivelse: Rat monoclonal antibody against mouse CD127, APC-conjugated.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Leverandør: STEMCELL Technologies

Beskrivelse: For detection and measurement of mouse interleukin 4.

New Product

Varenummer: (STMC200-0013)

Leverandør: STEMCELL Technologies

Beskrivelse: Custom-designed single guide RNA for CRISPR-Cas9 genome editing.

UOM: 1 * 1 Each

New Product Tilbud

 This is a MarketSource item. Additional charges may apply

Varenummer: (BWRLBS6162)

Leverandør: Bioworld Technology

Beskrivelse: Recombinant full length Human EMD.

UOM: 1 * 1 Each

Tilbud