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Image Unavailable-BOSSBS-12866R-A350

Anti-ARFGEF1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Varenummer: (BOSSBS-12866R-A350)
Leverandør: Bioss
Beskrivelse: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11861R-CY5

Anti-KALRN Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-11861R-CY5)
Leverandør: Bioss
Beskrivelse: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11861R-CY3

Anti-KALRN Rabbit Polyclonal Antibody (Cy3®)

Varenummer: (BOSSBS-11861R-CY3)
Leverandør: Bioss
Beskrivelse: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7761R-CY5

Anti-MYO7A Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-7761R-CY5)
Leverandør: Bioss
Beskrivelse: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12866R-FITC

Anti-ARFGEF1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Varenummer: (BOSSBS-12866R-FITC)
Leverandør: Bioss
Beskrivelse: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6476R-A350

Anti-BAZ1A Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Varenummer: (BOSSBS-6476R-A350)
Leverandør: Bioss
Beskrivelse: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6476R-CY5

Anti-BAZ1A Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-6476R-CY5)
Leverandør: Bioss
Beskrivelse: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.Component of the histone-fold protein complex CHRAC complex which faciliates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11861R-A488

Anti-KALRN Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Varenummer: (BOSSBS-11861R-A488)
Leverandør: Bioss
Beskrivelse: HAP1 (huntingtin-associated protein 1) binds to huntingtin (1). Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington’s disease (HD) (2,3). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region (1). HAP1 shows neuronal localization and moves with huntingtin in nerve fibers (4,5). HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem (1). Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons (6). Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12866R-CY5

Anti-ARFGEF1 Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-12866R-CY5)
Leverandør: Bioss
Beskrivelse: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.
UOM: 1 * 100 µl
Product Image-NEWPBOM402

Spaghetti booms, PIG®

Leverandør: NEW PIG
Beskrivelse: Surround and clean up thick oil spills on water with floating PIG® Spaghetti Booms.

Image Unavailable-BOSSBS-1402R-A350

Anti-SREBP-1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Varenummer: (BOSSBS-1402R-A350)
Leverandør: Bioss
Beskrivelse: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
UOM: 1 * 100 µl
Product Image-BURK0536-0010

Barrel valve

Varenummer: (BURK0536-0010)
Leverandør: BURKLE
Beskrivelse: The barrel valve for opening the barrel closure as well as emptying and reclosing it even with lying, full barrels without having to move them. Also used for highly viscous liquids.
UOM: 1 * 1 Items
Product Image-613-7116

VWR® Standard Line, Multi-Channel Pipettes, Mechanical, Variable Volume

Leverandør: VWR Collection
Beskrivelse: These lightweight Standard Line pipettes feature a revolutionary suspension system which allows the shaft to retract slightly when pressed against a row of pipette tips. Each shaft moves independently, resulting in an even sealing force being applied to all 8 or 12 tips. The suspension system not only ensures secure tip sealing, but also eliminates tips being jammed.

5 year warranty

Image Unavailable-BOSSBS-1402R-A488

Anti-SREBP-1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Varenummer: (BOSSBS-1402R-A488)
Leverandør: Bioss
Beskrivelse: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
UOM: 1 * 100 µl
Product Image-PRSI29-695

Anti-Semenogelin 1 Rabbit Polyclonal Antibody

Varenummer: (PRSI29-695)
Leverandør: ProSci Inc.
Beskrivelse: SEMG1 is the predominant protein in semen. The secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely.The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.
UOM: 1 * 1 Each
Product Image-JUSU35316

Lecture Bottle (LB) Gas Cylinder Holder

Leverandør: JUSTRITE MANUFACTURING
Beskrivelse: Lecture Bottle (LB) Gas Cylinder Holder provides safety when moving and storing of gas cylinders.

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Dette produkt er mærket som begrænset og kan kun købes af godkendte Shipping konti. Hvis du har brug for yderligere hjælp, e-mail VWR Regulatory Department på Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dette produkt er blevet blokeret for salg via hjemmesiden. Kontakt kundeservice for mere information.
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Produkt (er) markeret med dette symbol er udgået - sælges indtil lageret er tomt. Alternativer kan være tilgængelige ved at søge med VWR-katalognummeret ovenfor. Hvis du har brug for yderligere hjælp, bedes du kontakte kundeservice på telefon 4386 8788
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