Du Søgte efter: kappa-Carrageenan

Varenummer: (BOSSBS-5662R-A750)

Leverandør: Bioss

Beskrivelse: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).

UOM: 1 * 100 µl

Tilbud

Varenummer: (ABCAAB256420-100)

Leverandør: Abcam

Beskrivelse: Anti-Kappa light chain Mouse Monoclonal Antibody [clone: OX12] (Alexa Fluor® 488)

UOM: 1 * 100 µl

Tilbud

Varenummer: (USBIK0090-09A)

Leverandør: US Biological

Beskrivelse: Anti-Kappa light chain Mouse Monoclonal Antibody [clone: 6A101]

UOM: 1 * 1 mL

Tilbud

Varenummer: (USBIK0080-06)

Leverandør: US Biological

Beskrivelse: Anti-Kappa light chain Mouse Monoclonal Antibody [clone: 7H201]

UOM: 1 * 1 Each

Tilbud

Varenummer: (BOSSBS-20159R-A750)

Leverandør: Bioss

Beskrivelse: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalisation as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells.

UOM: 1 * 100 µl

Tilbud

Varenummer: (USBI038926-FITC)

Leverandør: US Biological

Beskrivelse: Anti-NF kappa B Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

UOM: 1 * 200 µl

Tilbud

Varenummer: (USBI038922-HRP)

Leverandør: US Biological

Beskrivelse: Anti-NF kappa B Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

UOM: 1 * 200 µl

Tilbud

Varenummer: (USBI031066-FITC)

Leverandør: US Biological

Beskrivelse: Anti-Kappa light chain Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: HP6053]

UOM: 1 * 200 µl

Tilbud

Varenummer: (BOSSBS-7088R-CY3)

Leverandør: Bioss

Beskrivelse: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-7088R-A680)

Leverandør: Bioss

Beskrivelse: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-0627R-CY5.5)

Leverandør: Bioss

Beskrivelse: Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-0627R-CY7)

Leverandør: Bioss

Beskrivelse: Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. Isoform 2: Contributes to cervical carcinogenesis in part through the TNF-alpha-induced NF-kappa-B signaling pathway by interacting with the I-kappa-B-kinase (IKK) core complex.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-4962R-CY7)

Leverandør: Bioss

Beskrivelse: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-15581R-A350)

Leverandør: Bioss

Beskrivelse: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-3191R-A555)

Leverandør: Bioss

Beskrivelse: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011].

UOM: 1 * 100 µl

Tilbud

Varenummer: (ROCK012-001-332)

Leverandør: Rockland Immunochemicals

Beskrivelse: Rat IgG2a Kappa isotype control can be utilized as a control or standard reagent in Western Blotting, Flow Cytometry, and ELISA experiments where determination of sample isotype is important. Specific conditions should be optimized by user.

UOM: 1 * 1 Each

Tilbud