Du Søgte efter: achr

Varenummer: (BOSSBS-0598R-CY3)

Leverandør: Bioss

Beskrivelse: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-0598R-A555)

Leverandør: Bioss

Beskrivelse: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).

UOM: 1 * 100 µl

Tilbud

Varenummer: (PRSI92-515)

Leverandør: ProSci Inc.

Beskrivelse: Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is prominently expressed in adult muscle and enriched at the NMJ. Studies with cultured myotubes reveal that Coronin 6 regulates both agrin- and laminin-induced AChR clustering and is important for anchoring AChRs onto the actin cytoskeleton. Also, both the C-terminal region and a conserved Arg29 residue at the N terminus of Coronin 6 are essential for its actin-binding activity and stabilisation of AChR–cytoskeleton linkage. Importantly, in vivo knockdown of Coronin 6 in mouse skeletal muscle fibers leads to destabilisation of AChR clusters, which demonstrates that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the NMJs through modulating the receptor-anchored actin cytoskeleton. The human Coronin 6 has five isoforms produced by alternative splicing, and tissue-specific expression of these isoforms are unclear.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI27-227)

Leverandør: ProSci Inc.

Beskrivelse: For background information on the acetylcholine receptor (AChR), see CHRNA1. Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit, which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity.For background information on the acetylcholine receptor (AChR), see CHRNA1 (MIM 100690). Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit (MIM 100725), which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity; MIM 142445).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2187 AK125362.1 1-2187

UOM: 1 * 1 Each

Tilbud

Varenummer: (USBI124981)

Leverandør: US Biological

Beskrivelse: Anti-CHRNE Mouse Monoclonal Antibody [clone: 6A2]

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI31-127)

Leverandør: ProSci Inc.

Beskrivelse: After binding acetylcholine, the ACHR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI31-100)

Leverandør: ProSci Inc.

Beskrivelse: After binding acetylcholine, the ACHR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

UOM: 1 * 1 Each

Tilbud

Varenummer: (PRSI79-946)

Leverandør: ProSci Inc.

Beskrivelse: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane.

UOM: 1 * 1 Each

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Varenummer: (GENOIT7516)

Leverandør: G-Biosciences

Beskrivelse: ELISA KIT N-ACHR RAT 1 * 1 Each

UOM: 1 * 1 Each

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Varenummer: (GENOIT4114)

Leverandør: G-Biosciences

Beskrivelse: ELISA KIT M-ACHR HUMAN 1 * 1 Each

UOM: 1 * 1 Each

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Varenummer: (GENOIT3707)

Leverandør: G-Biosciences

Beskrivelse: ELISA KIT ANTI-ACHR HUMAN 1 * 1 Each

UOM: 1 * 1 Each

Tilbud

Varenummer: (MOTI1101001701591)

Leverandør: MOTIC

Beskrivelse: [EN]OBJECTIVE ACHR. SUPER CONTRAST 60X/0 1 * 1 Items

UOM: 1 * 1 Items

Tilbud

Varenummer: (ANTIA74052-96)

Leverandør: ANTIBODIES.COM

Beskrivelse: [EN]ANTI-ACHR ANTIBODY ELISA 1 * 1 Each

UOM: 1 * 1 Each

New Product Tilbud

Varenummer: (OPTKM-774)

Leverandør: OPTIKA

Beskrivelse: [EN]40X LWD IOS PLAN ACHR. PHASE CONTRAS 1 * 1 Items

UOM: 1 * 1 Items

Tilbud

Varenummer: (BWRLBS60391)

Leverandør: Bioworld Technology

Beskrivelse: A synthetic peptide corresponding to residues in Human AChRalpha7.

UOM: 1 * 1 Each

Tilbud

Varenummer: (BWRLBS6951)

Leverandør: Bioworld Technology

Beskrivelse: Recombinant full length Human AChRalpha1.

UOM: 1 * 1 Each

Tilbud