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Image Unavailable-BOSSBS-4958R-A647

Anti-PCGF1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Varenummer: (BOSSBS-4958R-A647)
Leverandør: Bioss
Beskrivelse: PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6213R-A750

Anti-Estrogen Related Receptor gamma Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Varenummer: (BOSSBS-6213R-A750)
Leverandør: Bioss
Beskrivelse: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10235R-CY3

Anti-ZBTB7 Rabbit Polyclonal Antibody (Cy3®)

Varenummer: (BOSSBS-10235R-CY3)
Leverandør: Bioss
Beskrivelse: Pokemon, the POK erythroid myeloid ontogenic factor, not only regulates the expression of many genes, but also plays an important role in cell tumorigenesis. To investigate the molecular mechanism regulating expression of the Pokemon gene in humans, its 5'-upstream region was cloned and analyzed. Transient analysis revealed that the Pokemon promoter is constitutive. Deletion analysis and a DNA decoy assay indicated that the NEG-U and NEG-D elements were involved in negative regulation of the Pokemon promoter, whereas the POS-D element was mainly responsible for its strong activity. Electrophoretic mobility shift assays suggested that the NEG-U, NEG-D and POS-D elements were specifically bound by the nuclear extract from A549 cells in vitro. Mutation analysis demonstrated that cooperation of the NEG-U and NEG-D elements led to negative regulation of the Pokemon promoter. Moreover, the NEG-U and NEG-D elements needed to be an appropriate distance apart in the Pokemon promoter in order to cooperate. Taken together, our results elucidate the mechanism underlying the regulation of Pokemon gene transcription, and also define a novel regulatory sequence that may be used to decrease expression of the Pokemon gene in cancer gene therapy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6306R-CY7

Anti-GCM1 Rabbit Polyclonal Antibody (Cy7®)

Varenummer: (BOSSBS-6306R-CY7)
Leverandør: Bioss
Beskrivelse: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11188R-CY5

Anti-CEBPG Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-11188R-CY5)
Leverandør: Bioss
Beskrivelse: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1531R-HRP

Anti-ATF4/CREB-2 Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Varenummer: (BOSSBS-1531R-HRP)
Leverandør: Bioss
Beskrivelse: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6213R-A680

Anti-Estrogen Related Receptor gamma Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Varenummer: (BOSSBS-6213R-A680)
Leverandør: Bioss
Beskrivelse: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13224R-A680

Anti-FUBP1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Varenummer: (BOSSBS-13224R-A680)
Leverandør: Bioss
Beskrivelse: FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0516R-FITC

Anti-RARB Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Varenummer: (BOSSBS-0516R-FITC)
Leverandør: Bioss
Beskrivelse: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0516R-A680

Anti-RAR Beta Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Varenummer: (BOSSBS-0516R-A680)
Leverandør: Bioss
Beskrivelse: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6306R-A750

Anti-GCMA Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Varenummer: (BOSSBS-6306R-A750)
Leverandør: Bioss
Beskrivelse: Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3062R-HRP

Anti-CEBPB Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Varenummer: (BOSSBS-3062R-HRP)
Leverandør: Bioss
Beskrivelse: The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP alpha, CEBP delta, and CEBP gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL1 response element in the IL6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8452R

Anti-SNAPC3 Rabbit Polyclonal Antibody

Varenummer: (BOSSBS-8452R)
Leverandør: Bioss
Beskrivelse: SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5703R-CY3

Anti-STAT5B Rabbit Polyclonal Antibody (Cy3®)

Varenummer: (BOSSBS-5703R-CY3)
Leverandør: Bioss
Beskrivelse: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11188R-A680

Anti-CEBP gamma Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Varenummer: (BOSSBS-11188R-A680)
Leverandør: Bioss
Beskrivelse: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
UOM: 1 * 100 µl
Product Image-AGLSG7514A

SureVector

Varenummer: (AGLSG7514A)
Leverandør: AGILENT
Beskrivelse: Combine standard DNA components to build custom vector constructs from Agilent’s set of standard parts.
UOM: 1 * 1 Items
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