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Image Unavailable-BOSSBS-4539R-CY5.5

Anti-IL6 Rabbit Polyclonal Antibody (Cy5.5®)

Varenummer: (BOSSBS-4539R-CY5.5)
Leverandør: Bioss
Beskrivelse: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3980R-CY5

Anti-FBP1 Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-3980R-CY5)
Leverandør: Bioss
Beskrivelse: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2595R-CY5

Anti-IL1R2 Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-2595R-CY5)
Leverandør: Bioss
Beskrivelse: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
UOM: 1 * 100 µl
Image Unavailable-BNCB1087-500

Anti-CR2 Mouse Monoclonal Antibody (Biotin) [clone: FR5A10]

Leverandør: Biotium
Beskrivelse: Recognizes a protein of 140 kDa, which is identified as the complement receptor 2 (CR2)/CD21. Its epitope is located in 5-8 short consensus repeats (SCRs). This MAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. MAb FR5A10 can be used for EBV receptor studies, interactions between B and T cells especially through CD23, human complement receptor (CR2) studies and IFN-alpha receptor studies.

Image Unavailable-BNUM1087-50

Anti-CR2 Mouse Monoclonal Antibody (Purified, BSA-free) [clone: FR5A10]

Varenummer: (BNUM1087-50)
Leverandør: Biotium
Beskrivelse: Recognizes a protein of 140 kDa, which is identified as the complement receptor 2 (CR2)/CD21. Its epitope is located in 5-8 short consensus repeats (SCRs). This MAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. MAb FR5A10 can be used for EBV receptor studies, interactions between B and T cells especially through CD23, human complement receptor (CR2) studies and IFN-alpha receptor studies.
UOM: 1 * 50 µl
Image Unavailable-BOSSBS-11224R-A350

Anti-ATRIP Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Varenummer: (BOSSBS-11224R-A350)
Leverandør: Bioss
Beskrivelse: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.
UOM: 1 * 100 µl
Image Unavailable-30988-50MG

Supelco® TraceCERT® Organic Reference Standard, Flutolanil

Varenummer: (30988-50MG)
Leverandør: Merck
Beskrivelse: The flutolanil CRM may also find following uses: Examine the reproductive endpoints on the gonad endocrine system of the parental zebrafish after chronic exposure to different concentrations of flutolanil for 60 days. Spectroscopic analysis of acetamiprid flutolanil and etofenprox residues extracted from tomato fruits. Development and validation of two robust chromatographic methods for estimation of tomatoes specific acetamiprid flutolanil and etofenprox residues on fruits before food processing and serving. To investigate the developmental toxicity and the potential mechanism of thyroid endocrine disruption induced by flutolanil in zebrafish embryos based on H¹ NMR metabolomics analysis. To develop a sensitive LC-MS/MS analytical method for the determination of residual flutolanil and its principal metabolites and conjugates in livestock and seafood products.
UOM: 1 * 50 mg
Image Unavailable-BOSSBS-3001R-FITC

Anti-ACIN1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Varenummer: (BOSSBS-3001R-FITC)
Leverandør: Bioss
Beskrivelse: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3001R-A350

Anti-ACIN1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Varenummer: (BOSSBS-3001R-A350)
Leverandør: Bioss
Beskrivelse: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6843R-CY5.5

Anti-MAGED1 Rabbit Polyclonal Antibody (Cy5.5®)

Varenummer: (BOSSBS-6843R-CY5.5)
Leverandør: Bioss
Beskrivelse: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6843R-CY5

Anti-MAGED1 Rabbit Polyclonal Antibody (Cy5®)

Varenummer: (BOSSBS-6843R-CY5)
Leverandør: Bioss
Beskrivelse: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6843R-A750

Anti-MAGED1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Varenummer: (BOSSBS-6843R-A750)
Leverandør: Bioss
Beskrivelse: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds p75NTR and antagonizes its association with TrkA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. May act as a regulator of the function of DLX family members. May regulate p53 transcriptional activity and inhibit cell proliferation. Enhances p53 phosphorylation and accumulation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7725R-FITC

Anti-SA2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Varenummer: (BOSSBS-7725R-FITC)
Leverandør: Bioss
Beskrivelse: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7725R-HRP

Anti-SA2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Varenummer: (BOSSBS-7725R-HRP)
Leverandør: Bioss
Beskrivelse: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7725R

Anti-STAG2 Rabbit Polyclonal Antibody

Varenummer: (BOSSBS-7725R)
Leverandør: Bioss
Beskrivelse: Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2518R-CY5.5

Anti-CD74 Rabbit Polyclonal Antibody (Cy5.5®)

Varenummer: (BOSSBS-2518R-CY5.5)
Leverandør: Bioss
Beskrivelse: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
UOM: 1 * 100 µl
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