Du Søgte efter: 5-(Chlormethyl)uracil

Varenummer: (BOSSBS-1721R-A680)

Leverandør: Bioss

Beskrivelse: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-1721R-A555)

Leverandør: Bioss

Beskrivelse: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-6584R-A750)

Leverandør: Bioss

Beskrivelse: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-6584R-HRP)

Leverandør: Bioss

Beskrivelse: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-2950R-HRP)

Leverandør: Bioss

Beskrivelse: Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.

UOM: 1 * 100 µl

Tilbud

Leverandør: TCI

Beskrivelse: Uridine ≥98.0% (by HPLC, titration analysis)

Leverandør: Thermo Fisher Scientific

Beskrivelse: Appearance: White to light yellow Crystalline powder

MSDS

Leverandør: Thermo Fisher Scientific

Beskrivelse: 2'-Deoxyuridine 99+%

MSDS

Leverandør: Apollo Scientific

Beskrivelse: 4-(Chlormethyl)benzoylchlorid

Leverandør: Apollo Scientific

Beskrivelse: 5-Hydroxymethyluracil

Varenummer: (BOSSBS-2950R-A750)

Leverandør: Bioss

Beskrivelse: Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-8288R-HRP)

Leverandør: Bioss

Beskrivelse: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-8288R-A555)

Leverandør: Bioss

Beskrivelse: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.

UOM: 1 * 100 µl

Tilbud

Varenummer: (BOSSBS-2950R-CY7)

Leverandør: Bioss

Beskrivelse: Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4.

UOM: 1 * 100 µl

Tilbud

Leverandør: TCI

Beskrivelse: 2,2'-O-Cyclouridine ≥98.0% (by GC)

Leverandør: Apollo Scientific

Beskrivelse: 5-Chlormethyl-2-oxazolidinon 95%