Aristolochic acid 98, crystalline solid
Leverandør: Cayman ChemicalSamlet vurdering
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Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A₂ (PLA₂) activity (IC₅₀=40 µM in human neutrophils).
It inhibits human synovial fluid PLA₂-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA₂. Aristolochic acid inhibits hemolytic activity of PLA₂s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC₅₀s=4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib. Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.
Formel:
C₁₇H₁₁NO₇ Molekylvægt: 341.275 g/mol Opbevaringstemperatur: Fryser |
MDL Number:
MFCD00238539 CAS-nummer: 313-67-7 UN nummer: 1544 ADR: 6.1 III |
Specifikationer Testresultater
Purity | ≥98% |
Formulation | A Crystalline Solid |
λmax | 224, 320, 388 nm |
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