Anti-TNF Mouse Monoclonal Antibody (Purified) [clone: TNFA/1172]

Leverandør: Biotium
Ratings: Ingen bedømmelse

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BNUB1172-500 BNUB1172-100
BTIUBNUB1172-500EA 3810 DKK
BTIUBNUB1172-500 BTIUBNUB1172-100
Anti-TNF Mouse Monoclonal Antibody (Purified) [clone: TNFA/1172]
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This MAb recognizes human 17-26 kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Type: Primary
Antigen: TNF
Clonality: Monoclonal
Clone: TNFA/1172
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgM kappa
Reactivity: Human, Rat
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