Anti-CDKN1A Mouse Monoclonal Antibody (CF594) [clone: HJ21]

Leverandør: Biotium
Ratings: Ingen bedømmelse

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BNC940984-500 BNC940984-100
BNC940984-500EA 4180 DKK
BNC940984-500 BNC940984-100
Anti-CDKN1A Mouse Monoclonal Antibody (CF594) [clone: HJ21]
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This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. It is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Type: Primary
Antigen: CDKN1A
Clonality: Monoclonal
Clone: HJ21
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Chimpanzee, Human, Monkey, Mouse, Rat
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