Anti-CD63 Mouse Monoclonal Antibody (CF770) [clone: NKI-C3]

Leverandør: Biotium
Ratings: Ingen bedømmelse

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BNC700186-500 BNC700186-100
BNC700186-500EA 4180 DKK
BNC700186-500 BNC700186-100
Anti-CD63 Mouse Monoclonal Antibody (CF770) [clone: NKI-C3]
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This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

Type: Primary
Antigen: CD63
Clonality: Monoclonal
Clone: NKI-C3
Conjugation: CF770
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Mouse
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