Anti-C1orf124 Rabbit Polyclonal Antibody (Cy5®)

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BS-15013R-CY5
BOSSBS-15013R-CY5EA 6720 DKK
BOSSBS-15013R-CY5
Anti-C1orf124 Rabbit Polyclonal Antibody (Cy5®)
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Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading toMore Product Information
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