Anti-ERCC8 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

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BS-13095R-A350
BOSSBS-13095R-A350EA 6670 DKK
BOSSBS-13095R-A350
Anti-ERCC8 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
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Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribedMore Product Information
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